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The perform of SIK1 in tumorigenesis. SIK1 can be a tumor suppressor gene, which performs a very important regulatory part in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also prom